2009, discovery of a fresh phenotype for microbes in narrow nanofluidic slits; and initial detection of neighborhood protein constructions along DNA making use of reliable-condition nanopores
It was only from the 1990s while, when nanotechnology had State-of-the-art to a stage where solitary molecules can be manipulated, that the very first experimental products began to seem.
Within the similar time, the group of Paul McEuen, who was then centered within the University of California, Berkeley, showed very similar final results on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed applying scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of individual DNA molecules recaptured up to 1000 times in a solid point out nanopore
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Our investigation ranges through the biophysics of DNA to synthetic cells and over and above. Remember to take a look under with the spectrum of our recent assignments.
A lot of linked developments adopted, wherever our team founded distinctive transistor variants such as single-electron transistors at room temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into little proof-of-principle electronic circuits.
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
The rotors harness Electricity from a nanoscale h2o and ion stream which is generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and function autonomously in physiological conditions, suggesting tips on how to setting up energy-transducing motors at nanoscale interfaces.
Incredibly cool, but that wasn’t genuinely where my curiosity lay. I planned to pioneer and I had the feeling which was now not feasible, since the most attention-grabbing basic insights had by now been uncovered. But my field had designed lots of thrilling new equipment to evaluate individual molecules. I decided that I planned to utilize this to biology, to look at it from a physical perspective.’
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart structure in 2005. (nl)